RAF Typhoon FGR4s have operated alongside French aircraft in a coordinated attack against an hidden munitions depot in Syria operated by the Daesh militant organization, according to the UK's MoD.
The facility, located using reconnaissance, was believed to be containing munitions and bombs, the statement said, and was located in mountains just above Palmyra in Syria's central region.
"Our fighter planes utilized precision-guided Paveway IV munitions to hit a several access tunnels down to the site... early reports suggest the strike was effective," the MoD said.
There was no indication of any harm to civilians in the strike late on Saturday and each participating jet made a safe return, the MoD added.
The British jets were assisted by a Voyager aerial refuelling aircraft.
IS - referred to as ISIS - enforced jihadist rule over significant areas in Syria and Iraq before its territorial defeat in 2019.
"This strike demonstrates British leadership, and resolve to operate in unison with allied nations, to stamp out any resurgence of the terrorist group and their dangerous and violent ideologies in the region," UK Defence Secretary the minister remarked.
UK warplanes have conducted surveillance missions over Syrian airspace to "forestall any efforts to regroup" of the group subsequent to its defeat at the battle of Baghuz in the year 2019, the MoD reported.
"I must thank the personnel of the UK armed forces participating in this operation for their expertise and their courage," the Defence Secretary commented. "They were among thousands of British troops on duty over the holidays. This operation, to take out militants who pose a risk to our security, highlights how British military are ready to step up, throughout the year, keeping Britain secure domestically and influential overseas."
During December, the American forces executed what it described as a "massive strike" targeting Daesh sites in Syria, following an ambush killed two American soldiers and a civilian linguist in Palmyra.
The UN says Daesh still has between 5,000 and 7,000 militants in Syria and Iraq.